The decision to accept Ezzati’s resignation, announced in a Vatican statement on Saturday, comes at a time of sustained criticism of the Church’s response to a decades-long sexual abuse crisis.
Victims of sexual abuse by clergymen say a top-level conference at the Vatican last month failed to come up with concrete measures to tackle the issue.
On March 13 an Australian court sentenced former Vatican treasurer Cardinal George Pell to six years in prison for sexually abusing two choir boys in Melbourne - the most senior Catholic to be convicted for child sex offences. Pell is appealing.
Ezzati, 77, faces multiple charges of cover up, including some relating to the case of Oscar Munoz, a former top aide to the Santiago Archbishopric, who is facing trial on charges he abused and raped at least five children. He denies wrongdoing.